Choosing the Best Anti-HIV Med: Atripla Vs Truvada

With the introduction of several anti-HIV medications, it’s very challenging to find the right drug to fight the HIV virus. Some drugs are effective but extremely costly, some may cause severe adverse effects while others are much cheaper but have the same drug composition as those that are expensive. You have heard of Atripla, Truvada, and other cost-effective generics. Which is better? Let’s find out.

HIV treatment involves a lot of considerations. Like any other disease, before administering any medication, it’s very important that your doctor assess your health for any sign of threat that may arise if you use a particular drug.

The second factor is the drug’s effectiveness and tolerability. Confirming the likely side effects and weighing the drug’s active substances in fighting infection is necessary. But, it is very important to understand your health before taking any medicine.

Choosing the Best Anti-HIV Med: Atripla Vs TruvadaBoth Atripla and Truvada are high-quality and recommended anti-HIV drugs. While both meds serve the same purpose, a certain drug may be more effective or tolerable than the other, but both have higher prices.

To most patients, generic anti-HIV meds are their go-to solution. While we will cover this later, let’s look at the big picture: Atripla vs. Truvada.

What Are These Medications Used For?

As scientists head on finding the ultimate solution to cure the HIV virus, they have discovered highly effective remedies that can prevent fight the virus from multiplying in the body or prevent getting it in the first place.

Truvada involves the use of medicines that have the capability to effectively prevent the virus from entering your body when an individual engages in unsafe sex or is at a higher risk of HIV exposure. This phenomenon is called pre-exposure prophylaxis (or PrEP).

Once the virus enters your body, it attacks the body’s immune cells (CD4 cells or T-cells) and begins to make copies of itself. This is irreversible but can be managed by using anti-HIV drugs. Both Truvada and Atripla effectively treat the virus and make your immune function strong – giving you the ability to live healthier and longer, even with the virus.

Truvada Main Uses

Truvada is among the first choices of recommended drugs for preventing (as PrEP) and treating HIV/AIDS. It’s the most effective and tolerable drug, but available at a higher cost.

Truvada is designed with two active substances (emtricitabine and tenofovir) that effectively prevent the virus from entering your body (as PrEP) or from attacking the red blood cells through its replication action.

These active ingredients (HIV drugs) are two medicines that are combined in one pill to assist each other in fighting the virus. It belongs to the drug class NRTIs.

As PrEP, Truvada is used as a single dose, one pill daily, used alongside other recommended practices of safe sex like using a condom for maximum protection. Note that it doesn’t protect you from STIs.

What Is Atripla Prescribed For?

Atripla is an anti-HIV drug manufactured by Gilead Sciences. It contains three medicines – efavirenz, tenofovir, and emtricitabine antiviral medication that work together to effectively combat the HIV virus in the body.

Emtricitabine and tenofovir disoproxil belong to a class of drugs called NRTIs while efavirenz is an NNRTI. This makes the drug highly effective in inhibiting and attacking the virus since each of these drug classes works against the virus using a different approach (see the mode of action of this drug below).

Taken one tablet a day with or without meals. It’s preferable to take it in a dry state at least one hour before meals to decrease some side effects that may arise, such as drowsiness.

Does Truvada Work the Same Way As Atripla?

PrEP pillsTruvada and Atripla aim to decrease the level of the HIV virus in the body. Both have different ways of working once administered due to varying drug combinations. Truvada has two active substances belonging to the same drug class. Atripla has three drug combinations belonging to two drug classes.

While Truvada inhibits the virus-cell as an NRTIs, Atripla has a more complex approach in inhibiting the virus-cell using two different approach – as NRTIs and an NNRTI.

With the right formulation and virus targeting, both approaches accomplish the same function by fighting and preventing the virus from spreading in the body. It may seem that Atripla accomplishes more compared to Truvada. Nonetheless, both drugs are effective and give higher performance in fighting the virus and increasing CD4 cell count.

Let’s see how each drug functions in fighting the virus.

Truvada Mechanism of Action

Truvada’s active substance targets the virus by interfering with an enzyme known as reverse transcriptase. This enzyme is primarily used by the HIV-infected cells to produce new viruses.

Truvada inhibits these enzymes and reduces its primary activity, causing HIV-infected cells to stop making new viruses. Anti-HIV drugs do not completely wipe out the virus in the body. Once the white blood cell (or CD4 cell) is infected, the drug slows its replication process but does not completely kill the virus inside the cell.

In this approach, note that the CD4 cell or T-cell is primarily relied upon by the immune function. Once these cells are infected by the virus, they do not effectively carry their normal duties but are used by the virus to enrich itself. The more CD4 cells affected, the weaker the body’s immune system. Once Truvada inhibits these cells, it begins to increase in number, thus restoring your immune function. The end result? A stronger and healthier life.

Atripla Mode of Action

T-helper cellIn the same way as Truvada, Atripla has its own method of inhibiting and slowing or stopping the virus from making more copies of itself. Atripla consists of two drug classes, each with a target purpose.

Usually, HIV-infected cells use an enzyme called reverse transcriptase to make more copies or replicate. When Atripla inhibits this reverse transcriptase activity, it effectively manages to fight the virus and prevents/prohibits or reduces the virus replication process or stops it from producing newer viruses.

The result? CD4 cells take advantage of this enzyme (being inhibited by Atripla) and begin to resume making more copies of T-cells. When the virus is suppressed, its viral load is completely reduced. On the other hand, CD4+ cells are increased in number, resulting in a stronger immune function.

Anti-HIV treatment keeps the virus under control and consistent use of medication ensures that you keep the CD4 count higher and lead a stronger, healthier and longer life.

Truvada Versus Atripla: Comparison Chart

Even though the two drugs accomplish the same task, there is a lot that can be said about both drugs, from their similarities, differences, pros, cons and a lot more.

This comparison table will help you find a drug that can give you the ultimate tolerability with fewer side effects that can be manageable. It’s important to note that adverse reactions may occur as a result of your health. You don’t get these effects if you are in good health.

It’s always necessary to consult with a doctor and let him/her assess your health. Don’t forget to let them know of the other medicines you take. All of them – be it OTC, prescription, herbal remedies or recreational drugs.

Brand Name/Active Ingredient Truvada (emtricitabine/tenofovir) Atripla (efavirenz/emtricitabine/tenofovir)
Manufacturer Gilead Sciences Bristol-Myers Squibb and Gilead Sciences
Success Rate Truvada has a success rate of 99% when used for PrEP and more than a 70% success rate among individual injecting drugs. Combining multiple mechanisms of action in a single tab improves efficacy and maintains viral suppression compared to administering these agents independently
Drug Class Antiviral combinations – NRTIs Antiviral combinations – NRTIs + NNRTI
Approved by the U.S. FDA Aug 2, 2004 – for treating HIV/AIDS and in 2012 as PrEP. Jul 12, 2006, with an updated approval on Jan 11, 2010
Prescribed For
  • HIV/AIDS;
  • hepatitis B treatment;
  • PrEP.
HIV/AIDS treatment.
Effectiveness Research shows that Truvada for PrEP is highly effective and tolerable with a rate of 92-99 percent effectiveness in HIV prevention/acquisition (PrEP). Atripla as an anti-HIV treatment is highly effective as a 3-in-1 drug combination that’s well-tolerated and safe with an effective level of 92% to 98% undetectable viral load.
Dosage Forms Tablet; oral Tablet; oral
What Does It Look Like? Truvada pill Atripla tab
Consumption Instructions
  • recommended tablet per day is 1 pill either for PrEP or HIV/AIDS treatment – with or without a meal at the same time each day;
  • for PrEP, it is recommended to be used in combination with other practices of safe sex like using a condom;
  • administered alone as PrEP to prevent HIV-1 acquisition but it’s combined with other meds to fight HIV/AIDS.
  • Atripla for HIV/AIDS should be taken daily. Take only one tab a day with or without a meal;
  • since it’s a 3-in-1 tablet, it’s a complete antiretroviral regimen and cannot be taken with other HIV meds.
Half-Life Around 25.7 hours.

  • tenofovir – approx. 17 hours;
  • emtricitabine – approx. 10 hours.
Atripla’s half-life is 17 hours. Efavirenz’s terminal half-life is 52–76 hours, which changes to 40–55 hours after multiple doses.
Available Generics Currently, there are no generics of Truvada. Teva Pharmaceuticals will be the first pharma to produce a generic version of Truvada after its patent expires in 2020. Nonetheless, there are several generics having Truvada’s active substances for treating HIV or as PrEP. For example:

There are several other drugs that contain TDF/FTC.

Since Atripla has 3 medicines in 1 tab, a generic version must have the same active compounds, efficacy, and tolerability as the original Atripla. Here are some generic versions of Atripla:

  • Citenvir;
  • Truno;
  • Trivenz;
  • Trustiva;
  • Viraday;
  • Vonavir;
  • Heftenam;
  • Atreslawin;
  • Atroiza;
  • Odimune;
  • Tribuss;
  • Atenef.

And many more.

Brand Price (30 tabs) Cost for 30 tablets is $1,843.75 on average. Around $2,992 for a supply of 30 tablets.
Generic Price (30 tabs) Generic version of Truvada has the same active substance as Truvada but is sold at a much cheap price. In fact, most generics are more than 95% cheaper compared to the price of the branded version. For example, the prices of Ricovir-EM, Tenvir-EM, Tenof-EM, etc. are less than $2 per pill. From some pharmacies, you may get these tabs at a reduced cost if you order more. Just like the generic of Truvada, the generic version of Atripla has the same price range. You may get these tab at less than $2 if you order more. A drugstore like PrEPGeneric sells quality HIV medications at a substantially cheaper price. It’s the lowest ever, including other exclusive offers.
User Experience Great user experience comes from quality medication. This only comes if a drug optimally treats an illness. Truvada for PrEP is the first drug recommended by doctors as PrEP and HIV treatment due to its high efficacy and tolerability. Note that Truvada is effective in its drug formulation, but it may not be compared to Atripla – which is a 3-in-1 drug combination. Truvada is satisfactory for most patients as seen from reviews:

  • 100% of testimonials said Truvada is worth it (either as PrEP or HIV treatment);
  • 94% rate it as very effective (or work well in terms of effectiveness and tolerability).
Atripla is a drug that enjoys positive user experience, probably due to its 3-in-1 drug combination. Although it does not favor everyone due to its higher prices, a higher percentage of people have positive reviews on this drug’s effectiveness and ease of use. It’s highly effective, very well tolerated and comes with fewer adverse reactions: It scores 8.9/10 based on 101 reviews.
Main Interactions Truvada’s main interactions include:

  • hep C antiretroviral;
  • HIV-1 protease inhibitors like lopinavir/ritonavir;
  • meds affecting renal function, kidney and liver;
  • didanosine drugs.
Atripla may interact with diseases and other drugs if coadministered. Before taking this medication, make sure you consult with your doctor if you have these conditions or are using drugs to treat the following conditions:

  • hepatitis B;
  • HIV antiviral agents;
  • hepatotoxicity;
  • seizures;
  • cholesterol;
  • liver disease;
  • renal dysfunction;
  • QT prolongation;
  • hemodialysis;
  • drugs causing renal dysfunction;
  • bone toxicity;
  • mental symptoms.
Possible Adverse Reactions Drug reactions can occur with any medication. To avoid these problems, it’s important for your doctor to fully examine your health prior to using Truvada:

  • worsening of renal impairment;
  • can lead to worsening or onset of HBV in patients with HBV/HIV-1;
  • may cause immune reconstruction syndrome;
  • bone reduction;
  • buildup of lactic acidosis.
Atripla can cause some adverse reactions that can easily be managed if your doctor has access to your health information for analysis prior to administering this medication:

  • embryo-fetal toxicity;
  • bone loss/mineralization defects;
  • severe acute onset of hep B in patients having HIV-1 and HBV;
  • serious psychiatric symptoms;
  • worsened renal impairment problem;
  • hepatotoxicity;
  • adverse hypersensitivity reaction;
  • possible serious buildup of lactic acidosis;
  • rash;
  • nervous system symptoms.

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Which Medication Is Tolerated Better?

Drug tolerability is primarily based on individual health and drug administration. If a patient is in good health without major illnesses or using drugs that can interact with Truvada or Atripla, drug tolerability can be higher.

Contrarily, if you administer these drugs without first understanding your health through a doctor’s consultation to assess your health for possible interactions, then Truvada or Atripla can cause adverse reactions affecting the tolerability and safe dosage.

From looks, based on drug interactions and possible adverse reactions, Truvada can more tolerable compared to Atripla. But, if your health is good, Atripla can be the best drug to medicate HIV.

Real Reviews and Testimonials of Customers

Leave feedbackPatient reviews shed light on a particular medicine. When there are more positive reviews, it shows that the drug can be very effective and tolerable to most people. The opposite applies to more negative feedback.

It’s important to note that a patient review is a personalized view of how a particular drug responds to that person. But more reviews with the same experience gives a final but generalized outlook of a particular drug.

Truvada is favorable and among the first choices recommended for both PrEP and HIV/AIDS treatment. This also applies to Atripla for HIV medication.

Atripla scores a rate of 8.9/10 on its efficacy and tolerability. Truvada scores 4.5 from the same perspective. These two drugs go hand-in-hand together. The only difference is when you have some illnesses that can change which drug to best treat your condition.

Although both drugs come with a higher price tag, Truvada is somehow favorable at a slightly lower price.

Which Drug to Choose?

Looking for the best drug? What are your criteria? Maybe you are looking for the most effective anti-HIV or PrEP drug that is cheap. Both drugs are extremely expensive. Nonetheless, here is how we summarize the above-mentioned information to give you a conclusive outlook as to the right medicine:

Drug Name Pros Cons
Truvada
  • the active substances – TDF and FTC are the first two options recommended for treating HIV with other HIV drugs;
  • it’s the first recommended choice for PrEP medication;
  • it’s a daily one tab mediation for both HIV treatment and PrEP;
  • effective and tolerable in preventing and treating the HIV virus;
  • there are programs and initiatives that can cover the cost of Truvada.
  • you must apply other practices for safe sex if you are using Truvada as PrEP for maximum protection. Note that Truvada can’t protect you from acquiring STIs;
  • you must fulfill a 3-month mandatory health checkup and HIV test;
  • it’s advisable not to take Truvada if you are diagnosed with poorly functioning kidneys;
  • if you are diagnosed with both HIV and hep B, hepatitis B may be worsened if you stop using Truvada.
Atripla
  • highly effective and tolerable drug for HIV treatment. It’s among the first preferred choice for HIV treatment if other HIV meds combinations haven’t worked for you;
  • combines 3 medications into 1 pill to make it easy to take;
  • consistently take one tablet a day at the same time to keep the levels of Atripla high in the body;
  • there are excellent insurance and healthcare or government initiatives that help cover the cost of this drug.
  • to be used with caution if you have a history of seizures or osteoporosis because it can increase the risk of depression;
  • women should avoid becoming pregnant while taking Atripla;
  • not convenient for use in patients with poorly functioning kidneys;
  • possible risk of a severe allergic reaction.

Where to Buy Quality Medications Online Without Prescription?

Buy onlineMuch has been written about Truvada and Atripla. They have high efficacy and tolerability, making them top preferred choices for treating HIV. But their prices are ripping off the pockets of millions of people who strive to afford these medications.

But there is a path to overcome this. With approved, high-quality and effective generic counterparts to these medications, you get the same drug at an extremely cheap price.

It’s more than 90% cheaper compared to the cost of the original Truvada and Atripla. Generics contains exactly the same active ingredients as the brand-name version.

Moreover, since there are several generics of these drugs, it’s likely that there might be fake generic versions, too. Make sure you order your medications from the drugstore or supplier you trust. At PrEPGeneric, we sell quality anti-HIV and PrEP drugs that are FDA approved.

We have a variety of HIV treatment including Viraday, Instgra, Tafero-EM, Trustiva, Teevir, and more. We also have quality PrEP generics that thousands of our customers order, including Ricovir-EM, Tavin-EM, Tenof-EM, Tenvir-EM, and several others.

Our drugstore sells generic versions of Truvada and Atripla at a substantially cheaper cost. You get these cost-effective drugs from less than two dollars if you order in bulk. We also have exclusive coupons, discounts, and offers that you can grab and use to cut the cost of these meds. Interestingly, we give you 10% off your total cost if you checkout from our secure site with the Bitcoin payment option.

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