Tenofovir alafenamide is a substance approved by the FDA and used in the management of human immunodeficiency virus (HIV). It is highly effective, and it helps people infected with HIV live a longer, healthier life. Want to know how to get Vemlidy at a cheap price? Read more.
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When people contract HIV, the virus attacks their immune system and gradually breaks it down. Using an enzyme called reverse transcriptase, HIV replicates and damages TD4 cells and continues the process until the immune system is completely suppressed. This gives room for opportunistic infections such as cancer and PCP (a type of pneumonia) to attack the patient. Generic tenofovir alafenamide reduces the activity of the virus, thereby giving the immune system room to be revitalized. When used correctly, it can suppress the patient’s viral load to undetectable levels.
Tenofovir alafenamide fumarate is a prodrug of tenofovir and a reverse transcriptase inhibitor. It is also an active pharmaceutical ingredient used alongside darunavir/cobicistat/emtricitabine/tenofovir alafenamide fumarate in a fixed combination dose (FDC) for the possible treatment of HIV infection and hepatitis B.
An FDC drug is a drug that contains two or more active medicinal ingredients packed in capsules or tablets in a fixed dose.
Tenofovir alafenamide is an investigational drug. This means that it is under study and is not yet approved by the U.S. Food and Drug Administration (FDA).
Tenofovir AF Works by slowing down or preventing the replication process of the virus within the host, thus slowing down or preventing its growth. It does this by slipping into the bloodstream upon administration to inhibit an enzyme called reverse transcriptase.
Reverse transcriptase is an enzyme that enables HIV infected cells to make more copies of themselves (replicate). Enzymes are proteins that speed up chemical reactions. Because of its mode of action, tenofovir AF is classified under a class of HIV drugs called nucleoside reverse transcriptase inhibitors (NRTIs). Drugs in this class inhibit reverse transcriptase.
There are some side effects that may arise due to improper use of tenofovir AF. As such, certain precautions must be taken to prevent them. Here are some of the warnings of taking TAF, and associated precautions:
Here’s the catch. If a patient is co-infected with HBV and HIV-1, and takes Vemlidy alone, since the regimen doesn’t have the complete active ingredients required to tackle HIV-1, the virus could develop resistance to tenofovir alafenamide.
Vemlidy is one of several medicines used to treat chronic hepatitis B virus (HBV) in adults with compensated cirrhosis.
|Dosage tip for adults||It is recommended that adults take one tablet (25 mg) orally, once at the same time every day after eating.|
|Dosage tip for people with hepatic impairment||Patients with decompensated (Child-Pugh B or C) hepatic impairment are to avoid the use of Vemlidy. However, individuals with mild cases can take the regular dose of 25 mg once, at the same time daily.|
|Dosage tip for patients with renal impairment||Vemlidy is not recommended for patients whose impairment is in the end stage. However, patients with mild to moderate renal impairment can take the 25mg dose once daily, with food as well.|
25mg via oral administration should be taken once daily after meals for the treatment of HBV. However, before the commencement of the therapy, tests for the presence of HIV copies must be carried out. This is due to the fact that Vemlidy itself treats HBV, but requires combination with other antiretroviral (ARV) drugs for the treatment of HIV. If an individual unknowingly has HIV and attempts to tread HBV with alone, drug resistance may be developed.
NOTE: TAF monotherapy (i.e. using Vemlidy alone for treatment) should not be used for either hepatitis or HIV co-infection, but ONLY for hepatitis B virus infection. To treat the co-infection, tenofovir alafenamide must be combined with other ARV agents for best results.
You can discuss with a healthcare provider for more information about Vemlidy. He will also help you make a decision that best soothes you.
Possible side effects found to be associated with tenofovir AF include nausea, rash, and diarrhea. Unlike FDC drugs containing TDF, those with TAF have a better safety profile in terms of their effect on kidneys and bones.
However, this information is limited to the current findings obtained from the studies of the FDC regimen (darunavir/cobicistat/emtricitabine/tenofovir alafenamide). More information on possible side effects of the drug may surface as clinical trials continue.
TAF has been found to interact with medicines that induce p-glycoprotein, as it is a substrate of this plasma membrane protein (p-glycoprotein). Clinical trials have shown that inducers or inhibitors of this plasma membrane can cause either an unwanted increase in the plasma tenofovir concentrations or a decrease, as the case may be.
In view of this fact, p-glycoprotein inducers such as ritonavir and cobicistat should not be used alongside TAF, as they have been found to increase the concentration of the tenofovir content. On the other hand, drugs like rifabutin and rifampin (used for treating tuberculosis, TB), as well as supplements such as St. John's wort or anticonvulsants like phenobarbital, should not be co-administered with this drug as it can decrease tenofovir plasmas concentrations.
Tenofovir alafenamide was formulated not just to effectively provide sustained HIV viral suppression, but to do so safely with as minimal side effects as possible.
Long-term users of the medicine who were previously on some other regimen have attested to the characteristically mild nature of TAF. A majority of them stated that they no longer experience symptoms associated with the early stages of decrease in bone mineral density like they did while they were on some other meds. The have experienced symptoms such as muscle ache, decreased grip strength, and back pain.
On the other hand, many new users of the drug have given it a thumbs-up on account of its ease of use and effectiveness in suppressing the HIV viral load. One user categorically stated that going by the negative reviews given on some other HIV regimens, TAF seems to have performed beyond expectations.
However, there are a few users of the drug who have left negative reviews. Most of them were centered on discomforts experienced from the initial use of the drug. Generally, it is normal for some people to experience certain side effects such as headaches, fatigue, or nausea with initial use of TAF, but these effects improve after the first few days of using the drug correctly.
Chiefly, TAF has a highly favorable pharmacological profile, and concerns such as those associated with certain short and long-term adverse effects have been well taken care of. This is making Tenofovir alafenamide a preferred option in the world of effective pills for HIV treatment.
Generic tenofovir AF drugs are available at a lot of online pharmacy stores, and one can buy them at an affordable price. However, since there is no direct regulation of drugs sold online by the FDA, one may question their quality.
The way to go is to rely on certified online pharmacies that can be trusted any day, any time to deliver the best quality products to your doorstep. PrEPGeneric is one such pharmacy, and they can be counted on for low-cost, but highly effective drugs containing tenofovir alaninamide (Tafecta, HepBest), PrEP, anti-HIV pills, as well as medications for hepatitis.
PrEPGeneric offers loads of great benefits that users can enjoy when they shop at the store. Some of these benefits include more than 10 free samples so users can test the efficacy of the drugs before actually paying for them, discounts for bulk purchases, and coupon codes. The store also offers free shipping/tracking service for purchases over $250.